SYRACUSE, N.Y. (AP) - Ryan Nassib threw for 246 yards, Jerome Smith ran for 144 yards and Syracuse handed No. 11/9 Louisville its first loss of the season in a 45-26 victory on Saturday.
Playing in the last home game of his SU career, Nassib directed an offense that gained 524 total yards.
Nassib went 15 of 23 and passed Marvin Graves as the school's career leader in passing yards.
The Orange (5-5, 3-3) blew the game open with three touchdowns in the second quarter and Louisville (9-1, 4-1) allowed more points than it had in any game this season.
Teddy Bridgewater completed 36-of-49 passes for 426 and three touchdowns for Louisville.
It was a huge game for Syracuse, which has to win one of its final two games to achieve the six wins needed to play in a bowl game.
It was also Senior Day for a core group of players who have been key to helping coach Doug Marrone turn around a program that was a laughingstock not so long ago.